National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes.

I. OVERVIEW OF ANALYTICAL ISSUES FOR ACUTE CORONARY SYNDROME (ACS) BIOMARKERS ............................................................548 A. Analytical Issues: Background ..........................548 II. ANALYTICAL BIOMARKER ISSUES....................548 A. Cardiac Troponin Specifications .......................548 B. Cardiac Biomarker Turnaround........................549 C. Biomarkers No Longer Recommended for Use in the Context of ACS..............................................549 D. Determining Biomarker Decision Cutoff Characteristics for ACS ...................................................549 E. European Society of Cardiology (ESC)/American College of Cardiology (ACC) Recommendations ........................................................................550 III. REFERENCES .............................................................550 1 Hennepin County Medical Center, Minneapolis, MN. 2 Medical College of Virginia, Richmond, VA. 3 Duke University Medical Center, Durham, NC. 4 University of California at San Francisco, San Francisco, CA. 5 University of Maryland School of Medicine, Baltimore, MD. All relationships with industry for the guidelines committee are reported online at http://www.aacc.org/AACC/members/nacb/LMPG/OnlineGuide/ PublishedGuidelines/ACSHeart/heartpdf.htm . The materials in this publication represent the opinions of the authors and committee members, and do not necessarily represent the official position of the National Academy of Clinical Biochemistry (NACB) or the International Federation of Clinical Chemistry (IFCC). The National Academy of Clinical Biochemistry is the academy of the American Association for Clinical Chemistry. * Address correspondence to this author at: Director, Rapid Response Laboratories, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201. Fax 410-328-5880; e-mail [email protected]. This article has been copublished in the April 3, 2007 online issue of Circulation. Previously published online at DOI: 10.1373/clinchem.2006.084715 © 2007 American Association for Clinical Chemistry and the American Heart Association, Inc. Clinical Chemistry 53:4 547–551 (2007) Evidence-Based Laboratory Medicine and Test Utilization